Study of Diffusion Weighted Imaging Derived Diffusion Parameters as Biomarkers for the Microenvironment in Gliomas.

ABSTRACT:

Objectives

To explore the efficacy of diffusion weighted imaging (DWI)-derived metrics under different models as surrogate indicators for molecular biomarkers and tumor microenvironment in gliomas.

Methods

A retrospective study was performed for 41 patients with gliomas. The standard apparent diffusion coefficient (ADC_st) and ADC under ultra-high b values (ADC_uh) (b values: 2500 to 5000 s/mm²) were calculated based on monoexponential model. The fraction of fast diffusion (f), pseudo ADC (ADC_fast) and true ADC (ADC_slow) were calculated by bi-exponential model (b values: 0 to 2000 s/mm²). The apparent diffusional kurtosis (K_app) was derived from the simplified diffusion kur

SUBMITTER: Bai Y 

PROVIDER: S-EPMC8546342 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature