Role of the WOR1 Promoter of Candida albicans in Opaque Commitment.

ABSTRACT: During induced differentiation, the process often involves a commitment event, after which induced cells, when returned to noninducing conditions, continue to differentiate. The commitment event is rarely identified. Candida albicans differentiates from the white to opaque phenotype, a prerequisite for mating and a process accompanying colonization of the lower gastrointestinal tract and skin. In analyses of white cell populations induced to synchronously differentiate from the white to opaque phenotype, opaque commitment occurs at approximately the same time as evagination and chitin ring formation in the process of daughter cell formation, several hours after the master switch gene WOR1 is upregulated. Mutational analyses of transcription factor binding regions P1, P2, P3, P4, and

SUBMITTER: Conway TP 

PROVIDER: S-EPMC8546583 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature