Life Cycle Dominates the Volatilome Character of Dimorphic Fungus Coccidioides spp.

ABSTRACT: Valley fever (coccidioidomycosis) is an endemic fungal pneumonia of the North and South American deserts. The causative agents of Valley fever are the dimorphic fungi Coccidioides immitis and C. posadasii, which grow as mycelia in the environment and as spherules within the lungs of vulnerable hosts. Current diagnostics for Valley fever are severely lacking due to poor sensitivity and invasiveness, contributing to a 23-day median time to diagnosis, and therefore, new diagnostic tools are needed. We are working toward the development of a breath-based diagnostic for coccidioidomycosis, and in this initial study, we characterized the volatile metabolomes (or volatilomes) of in vitro cultures of Coccidioides Using solid-phase microextraction (SPME) and comprehensiv

SUBMITTER: Higgins Keppler EA 

PROVIDER: S-EPMC8546678 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature