SLAMF8 expression predicts the efficacy of anti-PD1 immunotherapy in gastrointestinal cancers.

ABSTRACT:

Objectives

Epstein-Barr virus (EBV) infection is associated with a better response to anti-PD1 immunotherapy. We hypothesised that genetic alterations induced by EBV infection are responsible for the activation of key immune responses and hence are predictive of anti-PD1 efficacy.

Methods

With transcriptome data of gastric cancer (GC), we explored differentially expressed genes (DEGs) specific for EBV infection and performed coexpression network analysis using the DEGs to identify the consistent coexpression genes (CCGs) between EBV-positive and EBV-negative GC tissues. We selected the tag genes of the CCGs and validated them using RNA sequencing and immunohistochemistry. We established murine models and collected tissues from clinical patients to test the value of SLAMF8

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC8546794 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature