Prognostic implications of ferroptosis-associated gene signature in colon adenocarcinoma.

ABSTRACT:

Background

Colon adenocarcinoma (COAD) is one of the most common and fatal malignant tumors, which increases the difficulty of prognostic predictions. Thus, new biomarkers for the diagnosis and prognosis of COAD should be explored. Ferroptosis is a recently identified programmed cell death process that has the characteristics of iron-dependent lipid peroxide accumulation. However, the predictive value of ferroptosis-related genes (FRGs) for COAD still needs to be further clarified.

Aim

To identify some critical FRGs and construct a COAD patient prognostic signature for clinical utilization.

Methods

The Cancer Genome Atlas database (TCGA) and Gene Expression Omnibus databases were the data sources for mRNA expression and corresponding COAD patient clinical information.

SUBMITTER: Miao YD 

PROVIDER: S-EPMC8546824 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature