Phylogenetic Distribution of Secondary Metabolites in the Bacillus subtilis Species Complex.

ABSTRACT: Microbes produce a plethora of secondary (or specialized) metabolites that, although not essential for primary metabolism, benefit them to survive in the environment, communicate, and influence cell differentiation. Biosynthetic gene clusters (BGCs), responsible for the production of these secondary metabolites, are readily identifiable on bacterial genome sequences. Understanding the phylogeny and distribution of BGCs helps us to predict the natural product synthesis ability of new isolates. Here, we examined 310 genomes from the Bacillus subtilis group, determined the inter- and intraspecies patterns of absence/presence for all BGCs, and assigned them to defined gene cluster families (GCFs). This allowed us to establish patterns in the distribution of both known and unknown produc

SUBMITTER: Steinke K 

PROVIDER: S-EPMC8546965 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature