Dual RNA Sequencing Meta-analysis in Plasmodium Infection Identifies Host-Parasite Interactions.

ABSTRACT: Dual RNA sequencing (RNA-Seq) is the simultaneous transcriptomic analysis of interacting symbionts, for example, in malaria. Potential cross-species interactions identified by correlated gene expression might highlight interlinked signaling, metabolic, or gene regulatory pathways in addition to physically interacting proteins. Often, malaria studies address one of the interacting organisms-host or parasite-rendering the other "contamination." Here we perform a meta-analysis using such studies for cross-species expression analysis. We screened experiments for gene expression from host and Plasmodium. Out of 171 studies in Homo sapiens, Macaca mulatta, and Mus musculus, we identified 63 potential studies containing host and parasite data. While 16 studies (1,950 s

SUBMITTER: Mukherjee P 

PROVIDER: S-EPMC8546971 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature