Circadian miR-449c-5p regulates uterine Ca²⁺ transport during eggshell calcification in chickens.

ABSTRACT:

Background

miRNAs regulate circadian patterns by modulating the biological clocks of animals. In our previous study, we found that the clock gene exhibited a cosine expression pattern in the fallopian tube of chicken uterus. Clock-controlled miRNAs are present in mammals and Drosophila; however, whether there are clock-controlled miRNAs in the chicken uterus and, if so, how they regulate egg-laying rhythms is unclear. In this study, we selected 18 layer hens with similar ovipositional rhythmicity (each of three birds were sacrificed for study per 4 h throughout 24 h); their transcriptomes were scanned to identify the circadian miRNAs and to explore regulatory mechanisms within the uterus of chickens.

Results

We identified six circadian miRNAs that are mainly associated with

SUBMITTER: Cui Z 

PROVIDER: S-EPMC8547053 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature