Comparative genomics reveals molecular mechanisms underlying health and reproduction in cryptorchid mammals.

ABSTRACT:

Background

Mammals have wide variations in testicular position, with scrotal testes in some species and ascrotal testes in others. Although cryptorchidism is hazardous to human health, some mammalian taxa are natural cryptorchids. However, the evolution of testicular position and the molecular mechanisms underlying the maintenance of health, including reproductive health, in ascrotal mammals are not clear.

Results

In the present study, comparative genomics and evolutionary analyses revealed that genes associated with the extracellular matrix and muscle, contributing to the development of the gubernaculum, were involved in the evolution of testicular position in mammals. Moreover, genes related to testicular position were significantly associated with spermatogenesis and sper

SUBMITTER: Chai S 

PROVIDER: S-EPMC8547080 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature