Identification and drug-induced reversion of molecular signatures of Alzheimer's disease onset and progression in App^NL-G-F, App^NL-F, and 3xTg-AD mouse models.

ABSTRACT:

Background

In spite of many years of research, our understanding of the molecular bases of Alzheimer's disease (AD) is still incomplete, and the medical treatments available mainly target the disease symptoms and are hardly effective. Indeed, the modulation of a single target (e.g., β-secretase) has proven to be insufficient to significantly alter the physiopathology of the disease, and we should therefore move from gene-centric to systemic therapeutic strategies, where AD-related changes are modulated globally.

Methods

Here we present the complete characterization of three murine models of AD at different stages of the disease (i.e., onset, progression and advanced). We combined the cognitive assessment of these mice with histological analyses and full transcriptional and p

SUBMITTER: Pauls E 

PROVIDER: S-EPMC8547095 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature