Impact of tight glucose control on circulating 3-hydroxybutyrate in critically ill patients.

ABSTRACT:

Background

Recent evidence suggests a potentially protective effect of increasing ketone body availability via accepting low macronutrient intake early after onset of critical illness. The impact of blood glucose control with insulin on circulating ketones is unclear. Whereas lowering blood glucose may activate ketogenesis, high insulin concentrations may have the opposite effect. We hypothesized that the previously reported protective effects of tight glucose control in critically ill patients receiving early parenteral nutrition may have been mediated in part by activation of ketogenesis.

Methods

This is a secondary analysis of 3 randomized controlled trials on tight versus liberal blood glucose control in the intensive care unit, including 700 critically ill children and

SUBMITTER: Gunst J 

PROVIDER: S-EPMC8547101 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature