Serum Individual Nonesterified Fatty Acids and Risk of Heart Failure in Older Adults.

ABSTRACT:

Background

Heart failure (HF) is highly prevalent among older adults and is associated with high costs. Although serum total nonesterified fatty acids (NEFAs) have been positively associated with HF risk, the contribution of each individual NEFA to HF risk has not been examined.

Objective

The aim of this study was to examine the association of individual fasting NEFAs with HF risk in older adults.

Methods

In this prospective cohort study of older adults, we measured 35 individual NEFAs in 2,140 participants of the Cardiovascular Health Study using gas chromatography. HF was ascertained using review of medical records by an endpoint committee.

Results

The mean age was 77.7 ± 4.4 years, and 38.8% were male. During a median follow-up of 9.7 (maximum 19.0) years, 6

SUBMITTER: Djousse L 

PROVIDER: S-EPMC8547188 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature