Association of Preoperative Depression and Anxiety With Long-term Opioid Use After Hysterectomy for Benign Indications.

ABSTRACT:

Objective

To assess whether preoperative depression or anxiety is associated with increased risk of long-term, postoperative opioid use after hysterectomy among women who are opioid-naïve.

Methods

We conducted an observational cohort study of 289,233 opioid-naïve adult women (18 years or older) undergoing hysterectomy for benign indications from 2010 to 2017 using IBM MarketScan databases. Opioid use and refills in the 180 days after surgery and preoperative depression and anxiety were assessed. Secondary outcomes included 30-day incidence of emergency department visits, readmission, and 180-day incidence of opioid complications. The association of depression and anxiety were compared using inverse-probability of treatment weighted log-binomial and proportional Cox regressio

SUBMITTER: Carey ET 

PROVIDER: S-EPMC8547203 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature