Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice.

ABSTRACT: Endometriosis is a chronic, estrogen-dependent gynecologic disorder that affects reproductive-aged women and to a lesser extent, post-menopausal women on hormone therapy. The condition is associated with systemic and local immune dysfunctions. While its underlying mechanisms remain poorly understood, endometriosis has a genetic component and propensity for the disease is subject to environmental, nutritional, and lifestyle influences. Previously, we showed that high-fat diet (HFD) increased ectopic lesion numbers, concurrent with systemic and peritoneal changes in inflammatory and oxidative stress status, in immunocompetent recipient mice ip administered with endometrial fragments null for Krüppel-like factor 9 gene. Herein, we determined whether HFD modifies lesion parameters, when

SUBMITTER: Heard-Lipsmeyer ME 

PROVIDER: S-EPMC8547326 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature