Virological measures and factors associated with outcomes, and missing outcome data in HIV clinical trials: a methodological study.

ABSTRACT:

Background

To evaluate the definition of HIV virological outcomes in the literature and factors associated with outcomes and missing outcome data.

Methods

We conducted a methodological review of HIV RCTs using a search (2009-2019) of PubMed, Embase and the Cochrane Central Register of Controlled Trials.Only full-text, peer-reviewed, randomised controlled trials (RCTs) that measured virological outcomes in people living with HIV, and published in English were included.We extracted study details and outcomes. We used logistic regression to identify factors associated with a viral threshold ≤50 copies/mL and linear regression to identify factors associated with missing outcome data.

Results

Our search yielded 5847 articles; 180 were included. A virological outcome was th

SUBMITTER: Youssef M 

PROVIDER: S-EPMC8547356 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature