Building Natural Product Libraries Using Quantitative Clade-Based and Chemical Clustering Strategies.

ABSTRACT: The success of natural product-based drug discovery is predicated on having chemical collections that offer broad coverage of metabolite diversity. We propose a simple set of tools combining genetic barcoding and metabolomics to help investigators build natural product libraries aimed at achieving predetermined levels of chemical coverage. It was found that such tools aided in identifying overlooked pockets of chemical diversity within taxa, which could be useful for refocusing collection strategies. We have used fungal isolates identified as Alternaria from a citizen-science-based soil collection to demonstrate the application of these tools for assessing and carrying out predictive measurements of chemical diversity in a natural product collection. Within Alternaria, differ

SUBMITTER: Anderson VM 

PROVIDER: S-EPMC8547436 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature