Carbohydrate Metabolism Affects Macrophage-Mediated Killing of Enterococcus faecalis.

ABSTRACT: Enterococcus faecalis, an opportunistic pathogen that causes severe community-acquired and nosocomial infections, has been reported to resist phagocyte-mediated killing, which enables its long-term survival in the host. Metabolism, especially carbohydrate metabolism, plays a key role in the battle between pathogens and hosts. However, the function of carbohydrate metabolism in the long-term survival of E. faecalis in phagocytes has rarely been reported. In this study, we utilized transposon insertion sequencing (TIS) to investigate the function of carbohydrate metabolism during the survival of E. faecalis in RAW264.7 cells. The TIS results showed that the fitness of carbohydrate metabolism-related mutants, especially those associated with fructose and mannose metabolism, were significantly

SUBMITTER: Wei L 

PROVIDER: S-EPMC8547443 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature