Mnt Represses Epithelial Identity To Promote Epithelial-to-Mesenchymal Transition.

ABSTRACT: The multistep process of epithelial-to-mesenchymal transition (EMT), whereby static epithelial cells become migratory mesenchymal cells, plays a critical role during various developmental contexts, wound healing, and pathological conditions such as cancer metastasis. Despite the established function of basic helix-loop-helix (bHLH) transcription factors (TFs) in cell fate determination, only a few have been examined for their role in EMT. Here, using transcriptome analysis of distinct stages during stepwise progression of transforming growth factor beta (TGFβ)-induced EMT in mammary epithelial cells, we revealed distinct categories of bHLH TFs that show differential expression kinetics during EMT. Using a short interfering RNA-mediated functional screen for bHLH TFs during EMT, we found Ma

SUBMITTER: Lavin DP 

PROVIDER: S-EPMC8547447 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature