Recent Advances in Epigenetic Biomarkers and Epigenetic Targeting in Prostate Cancer.

ABSTRACT:

Context

In addition to genetic alterations, epigenetic alterations play a crucial role during prostate cancer progression. A better understanding of the epigenetic factors that promote prostate cancer progression may lead to the design of rational therapeutic strategies to target prostate cancer more effectively.

Objective

To systematically review recent literature on the role of epigenetic factors in prostate cancer and highlight key preclinical and translational data with epigenetic therapies.

Evidence acquisition

We performed a systemic literature search in PubMed. At the request of the editors, we limited our search to articles published between January 2015 and August 2020 in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (

SUBMITTER: Kumaraswamy A 

PROVIDER: S-EPMC8547521 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature