MicroRNAs based regulation of cytokine regulating immune expressed genes and their transcription factors in COVID-19.

ABSTRACT:

Background

Coronavirus disease 2019 is characterized by the elevation of a broad spectrum of inflammatory mediators associated with poor disease outcomes. We aimed at an in-silico analysis of regulatory microRNA and their transcription factors (TF) for these inflammatory genes that may help to devise potential therapeutic strategies in the future.

Methods

The cytokine regulating immune-expressed genes (CRIEG) were sorted from literature and the GEO microarray dataset. Their co-differentially expressed miRNA and transcription factors were predicted from publicly available databases. Enrichment analysis was done through mienturnet, MiEAA, Gene Ontology, and pathways predicted by KEGG and Reactome pathways. Finally, the functional and regulatory features were analyzed and visua

SUBMITTER: Khokhar M 

PROVIDER: S-EPMC8547816 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature