An ultrasensitive molecularly imprinted polymer-based electrochemical sensor for the determination of SARS-CoV-2-RBD by using macroporous gold screen-printed electrode.

ABSTRACT: Herein, a novel molecularly imprinted polymer (MIP) based electrochemical sensor for the determination of the receptor-binding domain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2-RBD) has been developed. For this purpose, first, a macroporous gold screen-printed electrode (MP-Au-SPE) has been fabricated. The MIP was then synthesized on the surface of the MP-Au-SPE through the electro-polymerization of ortho-phenylenediamine in the presence of SARS-CoV-2-RBD molecules as matrix polymer, and template molecules, respectively. During the fabrication process, the SARS-CoV-2-RBD molecules were embedded in the polymer matrix. Subsequently, the template molecules were removed from the electrode by using alkaline ethanol. The template molecules removal was studied using cyclic vol

SUBMITTER: Amouzadeh Tabrizi M 

PROVIDER: S-EPMC8547854 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature