Mouse cochleostomy: a minimally invasive dorsal approach for modeling cochlear implantation.

ABSTRACT:

Objectives/hypothesis

The murine model has been used extensively to model and study human deafness. Technical difficulty in the surgical approach due to the small size of the tympanic bulla and a robust stapedial artery has limited its application for studies of cochlear implantation and electrical stimulation. We describe a minimally traumatic, stapedial artery-sparing approach to the round window that may be used to access the mouse cochlea for acute or chronic studies of implantation and stimulation.

Study design

Animal model.

Methods

Fifteen C57BL6J mice were used to validate this approach. Auditory brainstem response threshold and distortion product otoacoustic emissions were obtained preoperatively and 2 weeks postoperatively to determine hearing preservation re

SUBMITTER: Soken H 

PROVIDER: S-EPMC8547892 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature