Dynamic SARS-CoV-2-specific B-cell and T-cell responses following immunization with an inactivated COVID-19 vaccine.

ABSTRACT:

Objective

The dynamic adaptive immune responses elicited by the inactivated virus vaccine CoronaVac remain elusive.

Methods

In a prospective cohort of 100 healthcare professionals naïve for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who received two doses of CoronaVac, we analysed SARS-CoV-2-specific humoral and cellular responses at four different timepoints, including before vaccination (T1), 2 weeks after the first dose (T2), 2 weeks after the booster dose (T3), and 8-10 weeks after the booster dose (T4). SARS-CoV-2-specific antibodies, serum neutralizing activities, peripheral B cells, CD4⁺ and CD8⁺ T cells and their memory subsets were simultaneously measured in this cohort.

Results

SARS-CoV-2 spike-specific IgG responses r

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8547974 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature