Identification of Key Biomarkers and Pathways in Small-Cell Lung Cancer Using Biological Analysis.

ABSTRACT:

Background

Small-cell lung cancer (SCLC) is a major cause of carcinoma-related deaths worldwide. The aim of this study was to identify the key biomarkers and pathways in SCLC using biological analysis.

Methods

Key genes involved in the development of SCLC were identified by downloading three datasets from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were screened using the GEO2R online analyzer; for the functional annotation and pathway enrichment analysis of genes, Funrich software was used. Construction of protein-to-protein interaction (PPI) networks was accomplished using the Search Tool for the Retrieval of Interacting Genes (STRING), and network visualization and module identification were performed using Cytoscape.

Results

A

SUBMITTER: Liu H 

PROVIDER: S-EPMC8548101 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature