Kinetics of Neutralizing Antibody Response Underscores Clinical COVID-19 Progression.

ABSTRACT:

Background

Neutralizing antibody (nAb) response is generated following infection or immunization and plays an important role in the protection against a broad of viral infections. The role of nAb during clinical progression of coronavirus disease 2019 (COVID-19) remains little known.

Methods

123 COVID-19 patients during hospitalization in Tongji Hospital were involved in this retrospective study. The patients were grouped based on the severity and outcome. The nAb responses of 194 serum samples were collected from these patients within an investigation period of 60 days after the onset of symptoms and detected by a pseudotyped virus neutralization assay. The detail data about onset time, disease severity and laboratory biomarkers, treatment, and clinical outcome of these par

SUBMITTER: Lei Q 

PROVIDER: S-EPMC8548120 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature