A Novel S100 Family-Based Signature Associated with Prognosis and Immune Microenvironment in Glioma.

ABSTRACT:

Background

Glioma is the most common central nervous system (CNS) cancer with a short survival period and a poor prognosis. The S100 family gene, comprising 25 members, relates to diverse biological processes of human malignancies. Nonetheless, the significance of S100 genes in predicting the prognosis of glioma remains largely unclear. We aimed to build an S100 family-based signature for glioma prognosis.

Methods

We downloaded 665 and 313 glioma patients, respectively, from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) database with RNAseq data and clinical information. This study established a prognostic signature based on the S100 family genes through multivariate COX and LASSO regression. The Kaplan-Meier curve was plotted to compare overall survi

SUBMITTER: Hu Y 

PROVIDER: S-EPMC8548170 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature