Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities.

ABSTRACT: As coronavirus disease 2019 (COVID-19) threatens human health globally, infectious disorders have become one of the most challenging problem for the medical community. Natural products (NP) have been a prolific source of antimicrobial agents with widely divergent structures and a range vast biological activities. A dataset comprising 618 articles, including 646 NP-based compounds from 672 species of natural sources with biological activities against 21 infectious pathogens from five categories, was assembled through manual selection of published articles. These data were used to identify 268 NP-based compounds classified into ten groups, which were used for network pharmacology analysis to capture the most promising lead-compounds such as agelasine D, dicumarol, dihydroartemisinin and pyri

SUBMITTER: Luo L 

PROVIDER: S-EPMC8548270 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature