Analysis of whole exome sequencing in severe mental illness hints at selection of brain development and immune related genes.

ABSTRACT: Evolutionary trends may underlie some aspects of the risk for common, non-communicable disorders, including psychiatric disease. We analyzed whole exome sequencing data from 80 unique individuals from India coming from families with two or more individuals with severe mental illness. We used Population Branch Statistics (PBS) to identify variants and genes under positive selection and identified 74 genes as candidates for positive selection. Of these, 20 were previously associated with Schizophrenia, Alzheimer's disease and cognitive abilities in genome wide association studies. We then checked whether any of these 74 genes were involved in common biological pathways or related to specific cellular or molecular functions. We found that immune related pathways and functions related to innat

SUBMITTER: Mahadevan J 

PROVIDER: S-EPMC8548332 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature