Functional Abnormality Associated With Tau Deposition in Alzheimer's Disease - A Hybrid Positron Emission Tomography/MRI Study.

ABSTRACT: Objective: To investigate the characteristics of tau deposition and its impact on functional connectivity (FC) in Alzheimer's disease (AD). Methods: Hybrid PET/MRI scans with [¹⁸F]-THK5317 and neuropsychological assessments were undertaken in 26 participants with AD and 19 healthy controls (HC). The standardized uptake value ratio (SUVR) of [¹⁸F]-THK5317 PET imaging was compared between the AD and HC groups. Significant clusters that revealed higher tau deposition in the AD group compared to the HC group were selected as regions of interest (ROI) for FC analysis. We evaluated the difference in the FC between the two groups for each ROI pair. The clinical and radiological characteristics were compared between the AD patients with negative FC and AD patien

SUBMITTER: Fu L 

PROVIDER: S-EPMC8548365 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature