Adjuvant platinum-based chemotherapy in radically resected adrenocortical carcinoma: a cohort study.

ABSTRACT:

Background

After radical resection, patients with adrenocortical carcinoma (ACC) frequently experience recurrence and, therefore, effective adjuvant treatment is urgently needed. The aim of the study was to investigate the role of adjuvant platinum-based therapy.

Methods

In this retrospective multicentre cohort study, we identified patients treated with adjuvant platinum-based chemotherapy after radical resection and compared them with patients without adjuvant chemotherapy. Recurrence-free and overall survival (RFS/OS) were investigated in a matched group analysis and by applying a propensity score matching using the full control cohort (n = 268). For both approaches, we accounted for immortal time bias.

Results

Of the 31 patients in the platinum cohort (R0 n = 25, R

SUBMITTER: Kimpel O 

PROVIDER: S-EPMC8548516 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature