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AA amyloid in human food chain is a possible biohazard.

ABSTRACT: AA amyloidosis can be transmitted experimentally in several mammalian and avian species as well as spontaneously between captive animals, even by oral intake of amyloid seeds. Amyloid seeding can cross species boundaries, and fibrils of one kind of amyloid protein may also seed other types. Here we show that meat from Swedish and Italian cattle for consumption by humans often contains AA amyloid and that bovine AA fibrils efficiently cross-seed human amyloid β peptide, associated with Alzheimer's disease.

SUBMITTER: Rising A

PROVIDER: S-EPMC8548551 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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AA amyloid in human food chain is a possible biohazard.

Rising Anna A Gherardi Paola P Chen Gefei G Johansson Jan J Oskarsson Marie E ME Westermark Gunilla T GT Westermark Per P

Scientific reports 20211026 1

AA amyloidosis can be transmitted experimentally in several mammalian and avian species as well as spontaneously between captive animals, even by oral intake of amyloid seeds. Amyloid seeding can cross species boundaries, and fibrils of one kind of amyloid protein may also seed other types. Here we show that meat from Swedish and Italian cattle for consumption by humans often contains AA amyloid and that bovine AA fibrils efficiently cross-seed human amyloid β peptide, associated with Alzheimer' ...[more]

PMID: 34702933

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