Dysfunction of Resting-State Functional Connectivity of Amygdala Subregions in Drug-Naive Patients With Generalized Anxiety Disorder.

ABSTRACT: Objective: Although previous studies have reported on disrupted amygdala subregional functional connectivity in generalized anxiety disorder (GAD), most of these studies were conducted in GAD patients with comorbidities or with drug treatment. Besides, whether/how the amygdala subregional functional networks were associated with state and trait anxiety is still largely unknown. Methods: Resting-state functional connectivity of amygdala subregions, including basolateral amygdala (BLA) and centromedial amygdala (CMA) as seed, were mapped and compared between 37 drug-naïve, non-comorbidity GAD patients and 31 age- and sex-matched healthy controls (HCs). Relationships between amygdala subregional network dysfunctions and state/trait anxiety were examined using partial correlation

SUBMITTER: Wang M 

PROVIDER: S-EPMC8548605 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature