Children and Adults in a Household Cohort Study Have Robust Longitudinal Immune Responses Following SARS-CoV-2 Infection or Exposure.

ABSTRACT: Children have reduced severity of COVID-19 compared to adults and typically have mild or asymptomatic disease. The immunological mechanisms underlying these age-related differences in clinical outcomes remain unexplained. Here, we quantify 23 immune cell populations in 141 samples from children and adults with mild COVID-19 and their PCR-negative close household contacts at acute and convalescent time points. Children with COVID-19 displayed marked reductions in myeloid cells during infection, most prominent in children under the age of five. Recovery from infection in both children and adults was characterised by the generation of CD8 T_CM and CD4 T_CM up to 9 weeks post infection. SARS-CoV-2-exposed close contacts also had immunological changes over time despite no ev

SUBMITTER: Neeland MR 

PROVIDER: S-EPMC8548628 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature