Zinc Influx Restricts Enterovirus D68 Replication.

ABSTRACT: Enterovirus D68 (EV-D68) is a respiratory viral pathogen that causes severe respiratory diseases and neurologic manifestations. Since the 2014 outbreak, EV-D68 has been reported to cause severe complications worldwide. However, there are currently no approved antiviral agents or vaccines for EV-D68. In this study, we found that zinc ions exerted substantial antiviral activity against EV-D68 infection in vitro. Zinc salt treatment potently suppressed EV-D68 RNA replication, protein synthesis, and infectious virion production and inhibited cytopathic effects without producing significant cytotoxicity at virucidal concentrations (EC₅₀=0.033mM). Zinc chloride (ZnCl₂) treatment moderately inhibited EV-D68 attachment. Time-dose analysis of EV-D68 structural protein V

SUBMITTER: Liu S 

PROVIDER: S-EPMC8548656 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature