Cytochrome P450 1B1 Overexpression in Cervical Cancers: Cross-sectional Study.

ABSTRACT:

Background

Current standard treatments for patients with recurrent cervical cancer are not very effective and are associated with severe toxicity. Recently, the rational approach for the discovery of new therapies for cervical cancer is based on the alterations in the molecular biology of cancer cells. One of the emerging molecular changes in cancer cells is the aberrant expression of cytochrome P450 1B1 (CYP1B1). This unique enzyme has been reported to be selectively overexpressed in several cancers.

Objective

The aim of this study was to examine CYP1B1 expression in cervical cancers and to assess the enzyme's relationship with several clinicopathological features.

Methods

Immunohistochemistry was performed to examine CYP1B1 expression in 100 patient samples with cer

SUBMITTER: Alshammari FOFO 

PROVIDER: S-EPMC8548976 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature