Signaling-to-chromatin pathways in the immune system.

ABSTRACT: Complex organisms are able to respond to diverse environmental cues by rapidly inducing specific transcriptional programs comprising a few dozen genes among thousands. The highly complex environment within the nucleus-a crowded milieu containing large genomes tightly condensed with histone proteins in the form of chromatin-makes inducible transcription a challenge for the cell, akin to the proverbial needle in a haystack. The different signaling pathways and transcription factors involved in the transmission of information from the cell surface to the nucleus have been readily explored, but not so much the specific mechanisms employed by the cell to ultimately instruct the chromatin changes necessary for a fast and robust transcription activation. Signaling pathways rely on cascades of pro

SUBMITTER: Martinez de Paz A 

PROVIDER: S-EPMC8548991 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature