Urine TERT promoter mutations-based tumor DNA detection in patients with bladder cancer: A pilot study.

ABSTRACT: Telomerase reverse transcriptase (TERT) promoter mutations are the most frequent genetic events in bladder cancer (BC). The aim of the present pilot study was to evaluate the diagnostic potential of urine TERT promoter mutations-based liquid biopsy in patients with an ongoing oncological process, as well as in post-resection patients at risk of BC recurrence. A total of 60 patients were enrolled, of whom 27 patients had histologically proven BC; 23 had no signs of BC (control group); and 10 patients underwent transurethral malignancy resection 3-6 months prior to urine donation ('second look' group). Urine TERT promoter mutations were detected using Droplet Digital PCR. Receiver operating characteristic curve analysis revealed significant diagnostic power of the present approach (area unde

SUBMITTER: Jain M 

PROVIDER: S-EPMC8548999 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature