A nomogram-based immunoprofile predicts clinical outcomes for stage II and III human colorectal cancer.

ABSTRACT: An immunoscore for colorectal cancer (CRC) has higher prognostic significance than the TNM staging system. However, the tumor immune microenvironment contains various components that affect clinical prognosis. Therefore, a broader range of immune markers is required to establish an accurate immunoprofile to assess the prognosis of patients with CRC. Using immunohistochemistry combined with multispectral immunohistochemistry and objective assessments, the infiltration of four immune cell types (CD4⁺/CD8⁺/forkhead box p3⁺/CD33⁺ cells), as well as the expression of six co-signaling molecules [programmed cell death 1 (PD1) ligand 1/PD1/T-cell immunoglobulin mucin family member 3/lymphocyte-activating 3/tumor necrosis factor receptor superfamily, memb

SUBMITTER: Wang L 

PROVIDER: S-EPMC8549000 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature