Reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion.

ABSTRACT:

Aims

Insulin sensitivity and insulin secretion can be estimated by multiple indices from fasting blood samples or blood samples obtained during oral glucose tolerance tests. The test-retest reliability of these indices in repeated measurements within the same individuals can strongly vary.

Methods

We analyzed data of persons without diabetes who underwent two repeated OGTTs. For each measurement pair, we calculated multiple commonly used indices for the assessment of insulin secretion and insulin sensitivity. We then evaluated the coefficient of variation (standard deviation/mean) and discriminant ratio for each index.

Results

89 persons underwent two OGTTs with a median interval of 86 days (IQR 64-249). Among indices of insulin sensitivity derived from fasting blood

SUBMITTER: Hudak S 

PROVIDER: S-EPMC8549015 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature