Unexpected Disparity in Photoinduced Reactions of C₆₀ and C₇₀ in Water with the Generation of O₂ ^•- or ¹O₂.

ABSTRACT: Well-defined fullerene-PEG conjugates, C₆₀-PEG (1) and two C₇₀-PEG (2 and 3 with the addition sites on ab-[6,6] and cc-[6,6]-junctions), were prepared from their corresponding Prato monoadduct precursors. The resulting highly water-soluble fullerene-PEG conjugates 1-3 were evaluated for their DNA-cleaving activities and reactive oxygen species (ROS) generation under visible light irradiation. Unexpectedly, photoinduced cleavage of DNA by C₆₀-PEG 1 was much higher than that by C₇₀-PEG 2 and 3 with higher absorption intensity, especially in the presence of an electron donor (NADH). The preference of photoinduced ROS generation from fullerene-PEG conjugates 1-3 via t

SUBMITTER: Liosi K 

PROVIDER: S-EPMC8549049 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature