PiRNA-IPdb: a PIWI-bound piRNAs database to mining NGS sncRNA data and beyond.

ABSTRACT:

Background

PIWI-interacting RNAs (piRNAs) are an abundant single-stranded type of small non-coding RNAs (sncRNAs), which initially were discovered in gonadal cells, with a role as defenders of genomic integrity in the germline, acting against the transposable elements. With a regular size range of 21-35 nt, piRNAs are associated with a PIWI-clade of Argonaute family proteins. The most widely accepted mechanisms of biogenesis for piRNAs involve the transcription of longer precursors of RNAs to be processed, by complexes of proteins, to functional size, preferentially accommodating uridine residues at the 5' end and 3' methylation to increase the stability of these molecules. piRNAs have also been detected in somatic cells, with diverse potential functions, indicating their high plas

SUBMITTER: Barrenada O 

PROVIDER: S-EPMC8549166 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature