Anti-SARS-CoV-2 IgA Identifies Asymptomatic Infection in First Responders.

ABSTRACT:

Background

Immunoglobulin A (IgA) is an important component of the early immune response to SARS-CoV-2. Prior serosurveys in high-risk groups employing IgG testing alone have provided discordant estimates. The potential added benefit of IgA in serosurveys has not been established.

Methods

Longitudinal serosurvey of first responders (police, emergency medical service providers, fire fighters, and other staff) employing 3 serologic tests (anti-spike IgA, anti-spike IgG, and anti-nucleocapsid IgG) correlated with surveys assessing occupational and nonoccupational risk, exposure to COVID-19, and illnesses consistent with COVID-19.

Results

Twelve percent of first responders in Colorado at baseline and 22% at follow-up were assessed as having SARS-CoV-2 infection. Five perc

SUBMITTER: Montague BT 

PROVIDER: S-EPMC8549282 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature