FABP4 is an independent risk factor for lymph node metastasis and poor prognosis in patients with cervical cancer.

ABSTRACT:

Background

Pelvic lymph node metastasis (LNM) is a crucial independent prognostic factor in cervical cancer (CCa) and serves as an indicator for radiation therapy as the primary or an adjuvant treatment option. However, preoperative diagnosis of LNM remains challenging. Thus, we aimed to identify biomarkers of LNM in patients with presumed early-stage CCa.

Methods

The differentially expressed genes (DEGs) between tumours with different lymph node statuses were identified by using The Cancer Genome Atlas database. Then, univariate Cox regression analysis and Kaplan-Meier analyses were utilized to screen overall survival (OS)-associated genes. Multivariate Cox analysis and logistical analysis were utilized to evaluate independent risk factors for OS and LNM, respectively. Subs

SUBMITTER: Li G 

PROVIDER: S-EPMC8549317 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature