Aurora-A kinase is differentially expressed in the nucleus and cytoplasm in normal Mullerian epithelium and benign, borderline and malignant serous ovarian neoplasms.

ABSTRACT:

Background

Aurora-A kinase is important for cellular proliferation and is implicated in the tumorigenesis of several malignancies, including of the ovary. Information regarding the expression patterns of Aurora-A in normal Müllerian epithelium as well as benign, borderline and malignant epithelial ovarian neoplasms is limited.

Methods

We investigated Aurora-A expression by immunohistochemistry in 15 benign, 19 borderline and 17 malignant ovarian serous tumors, and 16 benign, 8 borderline, and 2 malignant ovarian mucinous tumors. Twelve fimbriae from seven patients served as normal Müllerian epithelium controls. We also examined Aurora-A protein expression by western blot in normal fimbriae and tumor specimens.

Results

All normal fimbriae (n = 12) showed nuclear but no

SUBMITTER: Alkhateeb KJ 

PROVIDER: S-EPMC8549328 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature