Effectiveness of oseltamivir treatment on clinical failure in hospitalized patients with lower respiratory tract infection.

ABSTRACT:

Background

Influenza is associated with excess morbidity and mortality of individuals each year. Few therapies exist for treatment of influenza infection, and each require initiation as early as possible in the course of infection, making efficacy difficult to estimate in the hospitalized patient with lower respiratory tract infection. Using causal machine learning methods, we re-analyze data from a randomized trial of oseltamivir versus standard of care aimed at reducing clinical failure in hospitalized patients with lower respiratory tract infection during the influenza season.

Methods

This was a secondary analysis of the Rapid Empiric Treatment with Oseltamivir Study (RETOS). Conditional average treatment effects (CATE) and 95% confidence intervals were computed from caus

SUBMITTER: Wiemken TL 

PROVIDER: S-EPMC8549332 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature