Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers.

ABSTRACT:

Background

The function of collagen triple helix repeat containing 1 (CTHRC1) as an oncogene has been reported in a growing number of publications. Bioinformatics methods represent a beneficial approach to examine the mechanism and function of the CTHRC1 gene in the disease process of cancers from a pan-cancer perspective.

Methods

In this study, using the online databases UCSC, NCBI, HPA, TIMER2, Oncomine, GEPIA, UALCAN, cBioPortal, COSMIC, MEXPRESS, STRING, CCLE, LinkedOmics, GTEx, TCGA, CGGA, and SangerBox, we focused on the relationship between CTHRC1 and tumorigenesis, progression, methylation, immunity, and prognosis. qPCR was used to detect CTHRC1 expression in glioma tissues and cell lines.

Results

The pan-cancer analysis showed that CTHRC1 was overexpressed in

SUBMITTER: Peng D 

PROVIDER: S-EPMC8549344 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature