Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova.

ABSTRACT: The evolution and emergence of drug-resistant tuberculosis (TB) has been studied extensively in some contexts, but the ecological drivers of these two processes remain poorly understood. This study sought to describe the joint evolutionary and epidemiological histories of a novel multidrug-resistant Mycobacterium tuberculosis strain recently identified in the capital city of the Republic of Moldova (MDR Ural/4.2), where genomic surveillance of drug-resistant M. tuberculosis has been limited thus far. Using whole genome sequence data and Bayesian phylogenomic methods, we reconstruct the stepwise acquisition of drug resistance mutations in the MDR Ural/4.2 strain, estimate its historical bacterial population size over time, and infer the migration history of this strain between

SUBMITTER: Brown TS 

PROVIDER: S-EPMC8549355 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature