A synthetic antibiotic class overcoming bacterial multidrug resistance.

ABSTRACT: The dearth of new medicines effective against antibiotic-resistant bacteria presents a growing global public health concern¹. For more than five decades, the search for new antibiotics has relied heavily on the chemical modification of natural products (semisynthesis), a method ill-equipped to combat rapidly evolving resistance threats. Semisynthetic modifications are typically of limited scope within polyfunctional antibiotics, usually increase molecular weight, and seldom permit modifications of the underlying scaffold. When properly designed, fully synthetic routes can easily address these shortcomings². Here we report the structure-guided design and component-based synthesis of a rigid oxepanoproline scaffold which, when linked to the aminooctose residue of clinda

SUBMITTER: Mitcheltree MJ 

PROVIDER: S-EPMC8549432 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature