Influence of Age on Calvarial Critical Size Defect Dimensions: A Radiographic and Histological Study.

ABSTRACT:

Abstract

Calvarial critical-size defect has been used to assess techniques and materials in the bone regeneration field. Previous studies utilized young adult rats with 3 months of age, which might not reflect the geriatric conditions. This study aimed to assess the dimensions of the calvarial critical-size defect in aged rats.Seventy-two rats in a randomized block design were allocated into a control young adult (11-12 weeks), and a test old group (22-24 months). Both groups were divided according to bone defect's size: 3 mm, 5 mm, and 7 mm defects, which were surgically created and followed for 4 and 8 weeks. Radiographic and histologic analyses were performed. Based on the results, additional groups with 4 mm defect size were added following the same protocols. Young groups yiel

SUBMITTER: Hudieb M 

PROVIDER: S-EPMC8549460 | biostudies-literature | 2021 Nov-Dec 01

REPOSITORIES: biostudies-literature