Mild Cystic Fibrosis Lung Disease Is Associated with Bacterial Community Stability.

ABSTRACT: Microbial communities in the airways of persons with CF (pwCF) are variable, may include genera that are not typically associated with CF, and their composition can be difficult to correlate with long-term disease outcomes. Leveraging two large data sets characterizing sputum communities of 167 pwCF and associated metadata, we identified five bacterial community types. These communities explain 24% of the variability in lung function in this cohort, far more than single factors like Simpson diversity, which explains only 4%. Subjects with Pseudomonas-dominated communities tended to be older and have reduced percent predicted FEV₁ (ppFEV₁) compared to subjects with Streptococcus-dominated communities, consistent with previous findings. To assess the predictive power of

SUBMITTER: Hampton TH 

PROVIDER: S-EPMC8549546 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature